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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
14.24
Human Site:
S1106
Identified Species:
22.38
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1106
D
E
E
E
N
E
E
S
D
N
E
K
E
T
E
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1132
K
A
A
E
E
D
E
T
Q
N
Q
H
D
D
S
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1118
K
A
A
E
E
D
E
T
Q
N
Q
H
D
D
S
Dog
Lupus familis
XP_537646
1532
174610
S1106
D
E
E
E
N
E
E
S
D
N
E
N
E
A
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
E1103
V
P
D
E
E
E
N
E
E
S
D
T
E
T
S
Rat
Rattus norvegicus
P41516
1526
173202
E1103
P
E
E
E
E
N
E
E
N
E
E
S
E
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S1134
G
E
E
E
N
E
D
S
E
N
E
K
E
T
E
Chicken
Gallus gallus
O42130
1553
174974
E1098
W
K
E
L
Q
N
K
E
E
E
E
G
D
E
S
Frog
Xenopus laevis
NP_001082502
1579
178601
E1096
K
Q
T
Q
E
K
E
E
A
G
E
L
I
E
E
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
E1102
D
A
Q
E
K
E
E
E
E
D
A
E
D
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
L1060
K
A
M
C
D
E
L
L
K
R
G
Y
R
P
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
A1120
L
I
K
M
K
F
D
A
D
P
V
K
K
W
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
R1060
R
M
E
L
Y
H
K
R
K
A
Y
L
E
G
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
P1076
Q
K
G
F
T
P
F
P
R
K
A
E
S
V
E
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
T1041
I
E
K
E
L
T
V
T
N
K
P
R
N
A
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
20
20
86.6
N.A.
26.6
46.6
N.A.
80
13.3
20
26.6
N.A.
6.6
N.A.
13.3
13.3
P-Site Similarity:
100
46.6
46.6
86.6
N.A.
53.3
60
N.A.
93.3
40
40
66.6
N.A.
20
N.A.
46.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
27
14
0
0
0
0
7
7
7
14
0
0
14
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
20
0
7
0
7
14
14
0
20
7
7
0
27
20
14
% D
% Glu:
0
34
40
60
34
40
47
34
27
14
40
14
40
14
40
% E
% Phe:
0
0
0
7
0
7
7
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
7
0
0
0
0
0
0
7
7
7
0
7
0
% G
% His:
0
0
0
0
0
7
0
0
0
0
0
14
0
0
0
% H
% Ile:
7
7
0
0
0
0
0
0
0
0
0
0
7
0
14
% I
% Lys:
27
14
14
0
14
7
14
0
14
14
0
20
7
0
7
% K
% Leu:
7
0
0
14
7
0
7
7
0
0
0
14
0
0
0
% L
% Met:
0
7
7
7
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
20
14
7
0
14
34
0
7
7
0
0
% N
% Pro:
7
7
0
0
0
7
0
7
0
7
7
0
0
7
0
% P
% Gln:
7
7
7
7
7
0
0
0
14
0
14
0
0
0
0
% Q
% Arg:
7
0
0
0
0
0
0
7
7
7
0
7
7
0
0
% R
% Ser:
0
0
0
0
0
0
0
20
0
7
0
7
7
7
27
% S
% Thr:
0
0
7
0
7
7
0
20
0
0
0
7
0
20
0
% T
% Val:
7
0
0
0
0
0
7
0
0
0
7
0
0
7
0
% V
% Trp:
7
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
0
0
0
7
0
0
0
0
0
7
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _